Denaturation map of polyoma DNA

The denaturation and the renaturation of the DNA of polyoma virus.

* Supported in part by a research contract NONR 266 (63) between the Office of Naval Research and Columbia University, and by a grant-in-aid from the Bristol-Myers Company. t Postdoctoral Research Fellow of the National Institute of Dental Research. Present address: National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland. t Present address: School of Dentistry, ...

Denaturation of Heterogeneous DNA

The effect of heterogeneous sequence composition on the denaturation of double stranded DNA is investigated. The resulting pair-binding energy variation is found to have a negligible effect on the critical properties of the smooth second order melting transition in the simplest (Peyrard-Bishop) model. However, sequence heterogeneity is dramatically amplified upon adopting a more realistic treat...

The replication of polyoma DNA.

Denaturation transition of stretched DNA.

In the last two decades, single-molecule force measurements using optical and magnetic tweezers and atomic force spectroscopy have dramatically expanded our knowledge of nucleic acids and proteins. These techniques characterize the force on a biomolecule required to produce a given molecular extension. When stretching long DNA molecules, the observed force-extension relationship exhibits a char...

Mechanical denaturation of DNA: existence of a low temperature denaturation

Recent theoretical predictions on DNA mechanical separation induced by pulling forces are numerically tested within a model in which self-avoidance for DNA strands is fully taken into account. DNA strands are described by interacting pairs of self avoiding walks (SAW) which are pulled apart by a force applied at the two extremities. The whole phase diagram is spanned by extensive Monte Carlo (M...